Non Animal Testing Database

A new 3D system to study multicellular tumor dynamics

December 2017
University of Freiburg, Freiburg, Germany
The study describes the development of a new method through the biofabrication of conical hydrogel wells to develop 3D spheroids of all types of cells, even of low-adhesive cells that usually do not form stable aggregates. Furthermore, the method allows the combination of different cell types to form multicellular aggregates and it provides direct access to the cell aggregates to use for different assays. With this method, the researchers show that bone marrow stromal cells enhance breast cancer cells 3D growth.
A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement
Per G. Lund
Added on: 07-11-2021
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