Non Animal Testing Database

New potential drug test in a breast cancer cell model

November 2016
Ludwig-Maximilians-Universität Munich-Innenstadt, Munich, Germany
The researchers test galectin-1 in different proliferation and apoptotic assays of monolayer and 3D cultures of human breast cancer cell lines. Galectin-1 is able to inhibit proliferation and metabolic cell activity and induce apoptosis in those cells that have high levels of Thomsen-Friedenreich antigen. The study shows galectin-1 efficiency in 3D tumor microenvironments.
Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model
Udo Jeschke
Added on: 07-11-2021
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