New potential drug test in a breast cancer cell model
November 2016
Ludwig-Maximilians-Universität Munich-Innenstadt, Munich, Germany
The researchers test galectin-1 in different proliferation and apoptotic assays of monolayer and 3D cultures of human breast cancer cell lines. Galectin-1 is able to inhibit proliferation and metabolic cell activity and induce apoptosis in those cells that have high levels of Thomsen-Friedenreich antigen. The study shows galectin-1 efficiency in 3D tumor microenvironments.
Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model
Udo Jeschke
Added on: 07-11-2021
[1] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2915-8[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
