A mathematical model to predict immune system response to CAR-T cell therapy
2018
Friends Select School, Philadelphia, USA(1)
Villanova University, Villanova, USA(2)
Villanova University, Villanova, USA(2)
CAR-T cell therapy is a novel therapy which can be used to treat blood cancers. However, CAR-T cells can cause a life-threatening side-effect called Cytokine Release Syndrome (CRS). The study uses a mathematical simulation to quantify the dynamics of 9 major cytokines for CAR-T cell therapy. The simulation results from this work can be used to generate hypotheses to optimize cytokine inhibition approaches in future experimental research to improve response to CAR-T cell therapy.
A model-based investigation of cytokine storm for T-cell therapy
Nan Fang(1), Yiming Pan(1), Brooks Hopkins(2), Zuyi Hang(2), Matthew Tucker(2)
Added on: 07-06-2021
[1] https://www.sciencedirect.com/science/article/pii/S2405896318316987[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
