Human fallopian tube organoid model for studies of chronic chlamydia infections
2019
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
The authors developed a human fallopian tube organoid model for the analysis of chronic chlamydia infections. Infected organoids exhibit a less differentiated phenotype with higher stemness potential, as well as a higher degree of DNA hypermethylation. These results suggest a long-term impact on the epithelium and imply a link to ovarian cancer.
Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
Thomas F. Meyer
Added on: 05-22-2020
[1] https://www.nature.com/articles/s41467-019-09144-7[2] https://www.bionity.com/en/news/1160168/organoids-reveal-inflammatory-processes-in-chlamydia-infections.html
