Modifications of progesterone receptors are involved in expression of breast cancer stem cell-associated genes
2017
University of Minnesota, Minneapolis, USA
Phosphorylation events of progesterone receptors (PR) have a major impact on their activity in breast cancer. In this study, they first screen modified PR in human breast cancer explants and make an assay with luminal 3D breast cancer model T47D treated with progestin or antiprogestins. The authors found that most explants had phosphorilation modifications and that these were associated with invasive lobular carcinoma and with the expression of genes that enable the maintenance of cancer stem cell fate.
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs
Carol A. Lange
Added on: 07-02-2021
[1] https://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0462-7[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
