Recovery of speech in stroke patients predicted by computer simulation
2021
Boston University, Boston, USA(1)
The University of Texas at Austin, Austin, USA(2)
The University of Texas at Austin, Austin, USA(2)
Predicting language therapy outcomes in bilinguals with aphasia (BWA) remains challenging due to the multiple pre-and post-stroke factors that determine the deficits and recovery of their two languages. Computational models that simulate language impairment and treatment outcomes in BWA can help predict therapy response and identify the optimal language for treatment. Here, the BiLex computational model is used to simulate the behavioural profile of language deficits and treatment response of a retrospective sample of 13 Spanish-English BWA who received therapy in one of their languages. Specifically, their pre-stroke naming ability and post-stroke naming impairment in each language were simulated, and their treatment response in the treated and the untreated language. BiLex predicted treatment effects accurately and robustly in the treated language and captured different degrees of cross-language generalization in the untreated language in BWA. A cross-validation approach further demonstrated that BiLex generalizes to predict treatment response for patients whose data were not used in model training. These findings support the potential of BiLex to predict therapy outcomes for BWA and suggest that computational modelling may be helpful to guide individually tailored rehabilitation plans for this population.
Predicting language treatment response in bilingual aphasia using neural network-based patient models
Claudia Peñaloza(1), Uli Grasemann(2)
Added on: 07-01-2021
[1] https://www.nature.com/articles/s41598-021-89443-6[2] https://www.technologynetworks.com/neuroscience/news/computer-simulations-of-the-brain-predict-stroke-recovery-349535
