New 3D model to assess activity of immunotherapy agents against cancer
CompanyNovember 2016
Roche Innovation Center Zurich, Schlieren, Switzerland
To enable better assessment of cancer immunotherapy agents in vitro, a three-dimensional model based on human cells was developed. This model includes tumor cells, fibroblasts and immune cells to mimic the complexity of the tumor environment particularly regarding tumor–host interactions. This new 3D model is shown fit to assess drug targeting, efficient stimulation of immune cell infiltration, and specific elimination of tumor or fibroblast areas.
A novel three‑dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents
Marina Bacac
Added on: 07-01-2021
[1] https://link.springer.com/article/10.1007/s00262-016-1927-1[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
