Dynamic model of SARS-CoV-2 spike protein reveals vaccine targets
2021
Max Planck Institute of Biophysics, Frankfurt, Germany
The spike protein of the SARS-CoV-2 virus is key for infection and the primary antibody target. However, the spike is covered by highly mobile glycan molecules that could impair antibody binding. To identify accessible epitopes, the researchers performed molecular dynamics simulations of an atomistic model of a glycosylated spike embedded in a membrane. By combining extensive simulations with bioinformatics analyses, they recovered known antibody binding sites and identified several epitope candidates as targets for further vaccine development. This computational epitope-mapping procedure is general and should thus prove useful for other viral envelope proteins which structures have been characterized.
Computational epitope map of SARS-CoV-2 spike protein
Gerhard Hummer
Added on: 05-11-2021
[1] https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008790[2] https://www.drugtargetreview.com/news/88523/dynamic-model-of-sars-cov-2-s-protein-reveals-vaccine-targets/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+RayBiotech+-+COVID-19+-+16.04.21&utm_term=Are+you+aware+of+the+latest+industry+updates+on+COVID-19%3f&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=cMeKWLIcPLmW5uBbhxQaMlS%2b2eTjmhr9GQeTLQvD3hzJKJVEWJGdNinw0rsfwmmKsHvZ1OhJelIUNElY5m2VKSyZj1jl0HDMNg0dqhZo%2bulmaJzT5kWkYUcFkH0X2VRjeaCnP6SHiux%2fhiDQQ6h2EMPNs6mcWO0GNAtXlTT3zxUcyrWflldOgrfD0H4qldryzDdeXr8RijnCCreQzT0T%2bpLO4CiEBc76jOHRI9c60J6RJSwtUpprZuH1NCHmr269
