Four subtypes of Alzheimer's disease identified by artificial intelligence
2021
Lund University, Lund, Sweden(1)
McGill University, Montréal, USA(2)
McGill University, Montréal, USA(2)
Previously, the pattern of spread of tau pathology in Alzheimer's disease (AD) was thought to be fairly uniform, but recent work has shown considerable variability in the distribution. Here, tau positron emission tomography scans of 1,612 individuals were performed and a computer program and artificial intelligence were used to look for distinctive patterns in the distribution of tau proteins. This revealed that there were four clearly distinguishable patterns for the distribution of tau proteins. The subtypes exhibited different demographic and cognitive profiles and had different longitudinal outcomes. In addition, network diffusion models implied that pathology in the different subtypes originates and propagates through different corticolimbic networks. The results suggest that a reexamination of the term "typical AD" based on a classification of tau pathology would be useful.
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Oskar Hansson(1), Jacob W. Vogel(2)
Added on: 05-11-2021
[1] https://www.nature.com/articles/s41591-021-01309-6#citeas
