Risk genes for haemorrhoidal diseases identified
2021
Christian-Albrechts-University of Kiel, Kiel, Germany(1)
CIC bioGUNE - BRTA, Derio, Spain(2)
CIC bioGUNE - BRTA, Derio, Spain(2)
Haemorrhoidal disease (HEM) affects a large amount of the population around the globe, however, the genetic predisposition is rarely understood. In order to determine genetic correlations, an analysis using the software METAL was performed including over 200.000 HEM patients and over 700.000 healthy individuals, By this, more than 102 gene loci were identified which seem to be linked to the disease. These genes' expression is enriched in blood vessels, gastrointestinal tissues as well as in pathways associated with smooth muscles, epithelial and endothelial development and morphogenesis. This provides new insights on HEM genetic predisposition and may help to identify individuals at risk in an early state.
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Andre Franke(1), Mauro D'Amato(2)
Added on: 05-05-2021
[1] https://gut.bmj.com/content/early/2021/04/22/gutjnl-2020-323868[2] https://www.bionity.com/en/news/1170778/large-scale-genetic-study-sheds-light-on-the-causes-of-hemorrhoids.html
