Functional neuromuscular organoids
2020
Max Delbrück Center for Molecular Medicine, Berlin, Germany
These functional neuromuscular organoids self-organize into spinal cord neurons and muscle tissue, which together form a complex neuronal network that directs muscle tissue to contract. To assess the potential of the neuromuscular organoids to study neuromuscular diseases, a myasthenia gravis model was created. Incubation of the organoids with serum obtained from patients resulted in fewer muscle contractions mirroring the muscle weakness experienced by patients.
Self-organizing 3D human trunk neuromuscular organoids
Mina Gouti
Added on: 05-13-2020
[1] https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30525-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590919305259%3Fshowall%3Dtrue[2] https://www.technologynetworks.com/cell-science/news/functional-neuromuscular-organoids-created-329476
