Breast carcinoma organoids with adipose tissue on chip
Eberhard Karls University Tübingen, Tuebingen, Germany
Although adipose tissue is a crucial component that serves as an active endocrine organ in the breast cancer microenvironment, not much is understood in terms of adipocytes role in breast cancer progression and metastasis, as the recapitulation of tumor heterogeneity and its complex microenvironment constitutes a major challenge.
In this Micro OrganoLab project, human primary breast cancer organoids and adipose tissue are combined to generate an immunocompetent Breast-Carcinoma-on-Chip model. This platform will enable the investigation of the underlying mechanism of adipose-carcinoma interactions and the determination of their effect on breast cancer progression. Furthermore, patient-specific effects driven by disease states (healthy vs. obese vs. diabetic), age (pre- and postmenopausal), as well as ethnicity can be recapitulated in this model as a guide for personalised cancer treatment.
Tumor-on-Chip: Breast-Carcinoma-on-Chip
Peter Loskill
Added on: 03-05-2021
[1] https://www.organ-on-chip.uni-tuebingen.de/projects/breast-carcinoma-on-chip/
