Non Animal Testing Database

Anti-cancer small-molecule polymerization

November 2020
Broad Institute of MIT and Harvard, Cambridge, USA(1)
Harvard Medical School, Boston, USA(2)
Using human cells, the study demonstrates that a small molecule such as BI-3802 can induce polymerization coupled to highly specific protein degradation, which in the case of B cell lymphoma 6 (BCL6) leads to increased pharmacological activity compared to the effects induced by other BCL6 inhibitors. These findings open new avenues for the development of therapeutic agents and synthetic biology.
Small-molecule-induced polymerization triggers degradation of BCL6
Benjamin L. Ebert(1), Eric S. Fischer(2)
Added on: 01-29-2021
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