Non Animal Testing Database

P.R.I.T. ExpoCube for toxicity screening of aerosols

Fraunhofer Institute for Toxicology and Exerimental Medicine, Hannover, Germany
The P.R.I.T. ExpoCube allows the use of cell cultures and tissues as air-liquid interface (ALI) cultures for testing inhalable substances from a variety of sources. Cells, ex vivo material, as well as precision-cut lung slices, can be exposed to gases, vapours, aerosols and subsequently analysed for cellular changes. This technology is compatible with commercial culture membranes and insert-multi-well plates. Cells are uniformly exposed to the aerosols in an efficient computer-controlled manner. During exposure, live-cell imaging allows for a direct online observation of cultures.
Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process
Detlef Ritter
Added on: 01-29-2021
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