Autologous four-organ-chip
Company 2019
TissUse GmbH, Berlin, Germany
In this study, a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents was investigated. All four organ models were predifferentiated from induced pluripotent stem cells from the same healthy donor and integrated into the microphysiological system. Coculture of the four autologous tissue models in one common medium deprived of tissue-specific growth factors was successful over 14 days. Intestine, liver and neuronal model maintained defined marker expression. The renal model was overgrown by coexisting cells and did not further differentiate.
Autologous induced pluripotent stem cell-derived four-organ-chip
Anja Patricia Ramme
Added on: 12-23-2020
[1] https://www.future-science.com/doi/10.2144/fsoa-2019-0065
