New cancer diagnostics: A glimpse into the tumor in 3D
October 2020
TU Wien, Vienna, Austria
The authors describe a novel approach that allows pathologists to three-dimensionally analyse malignant tissues, including the tumour-host tissue interface. The visualization technique utilizes a combination of ultrafast chemical tissue clearing and light-sheet microscopy to obtain virtual slices and 3D reconstructions of up to multiple centimetre-sized tumour resectates. Since the imaging of several thousands of optical sections is a fast process, it is possible to analyse a larger part of the tumour than by mechanical slicing. As this also adds further information about the 3D structure of malignancies, the technology will probably become a valuable addition for histological diagnosis in clinical pathology.
3D histopathology of human tumours by fast clearing and ultramicroscopy
Inna Sabdyusheva Litschauer, Hans-Ulrich Dodt
Added on: 11-06-2020
[1] https://www.nature.com/articles/s41598-020-71737-w[2] https://www.bionity.com/en/news/1168417/new-cancer-diagnostics-a-glimpse-into-the-tumor-in-3d.html
