Human bone marrow-chip reveals mechanisms underlying genetic disorders
2020
Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, USA
Bone marrow cells are cultured from patient cells on a chip. Patients' pathophysiologies are reflected by their corresponding bone marrow cultures. Studies using bone marrow-chips reveal molecular information on genetic disorders. Bone marrow defects were investigated, induced by radiation, medication or genetic defects.
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
Donald E. Ingber
Added on: 05-05-2020
[1] https://www.nature.com/articles/s41551-019-0495-z[2] https://wyss.harvard.edu/news/successfully-predicting-bone-marrow-failure-caused-by-drugs-radiation-and-disease/?utm_source=hs_email&utm_medium=email&utm_content=82223516&_hsenc=p2ANqtz-_sOA7DgZ3DfQ4Winy1PVEnOj_JB4igmAEWngYmCdX-hGK-NeB0JIjCxpcYRpM3xzMc3vZprT7qoe7-pZvf5bTkbo3ZRg&_hsmi=82223516
