Brain scans show brain aging over the course of life depending on diseases and lifestyle
2018
Amen Clinics, Costa Mesa, USA
A large psychiatric cohort of 31,227 individuals received brain SPECT (Single Photon Emission Computed Tomography) at rest and during a concentration task. ANOVA (Analysis of Variance) was done to identify the mean age trends over the course of the age range in this group, 0-105 years. A regression model in which brain SPECT regions of interest were used to predict chronological age (CA) was then utilized to derive brain estimated age (BEA). The difference between CA and BEA was calculated to determine increased brain ageing in common disorders such as depression, dementia, substance use, and anxiety. Throughout the lifespan, variations in perfusion were observed in childhood, adolescence, and late-life. Increased brain ageing was seen in alcohol use, cannabis use, anxiety, bipolar, schizophrenia, attention-deficit/hyperactivity disorder, and in men. Brain SPECT can predict chronological age and this feature varies as a function of common psychiatric disorders.
Patterns of regional cerebral blood flow as a function of age throughout the lifespan
Daniel G. Amen
Added on: 07-09-2020
[1] https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180598[2] https://www.technologynetworks.com/neuroscience/news/largest-brain-study-of-62454-scans-identifies-drivers-of-brain-aging-307956?utm_cam
