Non Animal Testing Database

Cell transformation assay to detect carcinogenicity

validated method
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
The in vitro CTA using Bhas 42 cell line is aimed at detecting the carcinogenic potential of chemicals. The assay is based on the change of the phenotypic features of cells undergoing the first steps of the conversion from normal cells to neoplastic-like cell foci with oncogenic properties. The current protocols consist of two assay components, the initiation assay and the promotion assay to detect the tumour-initiating and tumour-promoting activity of chemicals, respectively. Validated and regulatory approved under TM2012-06 (EU) by EURL ECVAM (TSAR list), OECD Guidance Document 231.
Cell transformation assay based on the bhas 42 cell line
Added on: 07-03-2020
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