Non Animal Testing Database
EnglischDeutsch
Download XML for Micrsoft Excel
Download CSV for Microsoft Excel
Copy search query
Print / PDF

Cell transformation assay to detect carcinogenicity

Validated Method
2012
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
#cancer, #carcinogenicity, #chemicals, #regulatory acceptance
The in vitro CTA using Bhas 42 cell line is aimed at detecting the carcinogenic potential of chemicals. The assay is based on the change of the phenotypic features of cells undergoing the first steps of the conversion from normal cells to neoplastic-like cell foci with oncogenic properties. The current protocols consist of two assay components, the initiation assay and the promotion assay to detect the tumour-initiating and tumour-promoting activity of chemicals, respectively. Validated and regulatory approved under TM2012-06 (EU) by EURL ECVAM (TSAR list), OECD Guidance Document 231.
Cell transformation assay based on the bhas 42 cell line
EURL ECVAM

EURL ECVAM [1]   URL
OECD [2]   URL
#222
Added on: 07-03-2020
[1] https://tsar.jrc.ec.europa.eu/test-method/tm2012-06[2] https://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO(2016)1&doclanguage=en
Back to Top
English German
Project of


Supported by


Logo
Lush Prize Winner 2022


Lush Prize Winner 2022
Winner of the Animal Protection Prize of Lower Saxony 2022

Winner of the Animal Protection Prize of Lower Saxony 2022

Suscribe to RSS Feed Legal Notice Privacy Policy

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!