Unannotated RNAs as promising biomarkers for prostate cancer
2024
Icahn School of Medicine at Mount Sinai, New York, USA
Extracellular vesicles (EVs) are secreted by all cells and play important roles in communication and waste disposal. This study explores small unannotated RNAs from EVs, which may regulate gene expression and serve as potential biomarkers for prostate cancer. The researchers created an innovative bioinformatic pipeline to analyse RNA data from prostate cancer and benign tissues, revealing distinct expression patterns linked to unannotated genomic regions, termed "EV-UGRs." These EV-UGRs were significantly downregulated in the serum of patients with aggressive prostate cancer but were upregulated after radical prostatectomy. A new assay was developed to validate these findings for use in non-invasive diagnostics. Overall, this research highlights the potential of EV-UGRs as promising biomarkers for prostate cancer.
Extracellular vesicles carry transcriptional ‘dark matter’ revealing tissue-specific information
Gustavo Stolovitzky, Navneet Dogra
Added on: 12-19-2024
[1] https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.12481[2] https://www.drugtargetreview.com/news/152378/transforming-disease-diagnosis-with-new-nanoparticles/
