A blueprint for tumor-infiltrating B cells across human cancers
2023
Chinese Academy of Sciences, Shanghai, China(1)
Fudan University, Shanghai, China(2)
Zhejiang University, Hangzhou, China(3)
Fudan University, Shanghai, China(2)
Zhejiang University, Hangzhou, China(3)
Tumor-infiltrating B cells have emerged as important players in cancer immunity and served as predictors of response to immunotherapy. In this study, tumour-infiltrating B cells from 21 different types of cancer were examined using tissue and blood samples from patients, and single-cell transcriptome, B cell receptor repertoire, as well as chromatin accessibility data were compiled. Tumor-associated B cells were found to differentiate into antibody-secreting cells by either an extrafollicular pathway or by a more canonical germinal center pathway. Tumors associated with the extrafollicular B cell profile demonstrated poor clinical prognosis and resistance to immunotherapy compared with tumors harbouring germinal center B cells. Alterations in the availability of glutamine-derived metabolites, which are known to influence T cell–dependent immunosuppression, may be linked to a dysfunctional humoral response and the adverse effect of extrafollicular B cells on tumors.
A blueprint for tumor-infiltrating B cells across human cancers
Xiaoming Zhang(1), Jia Fan(2), Qiang Gao(2), Guoji Guo(3)
Added on: 08-05-2024
[1] https://www.science.org/doi/10.1126/science.adj4857
