3D liver-on-chip model for drug and toxicity studies
CompanyDynamic42 GmbH, Jena, Germany
The three-dimensional liver-on-chip model from Dynamic42 validly recapitulates the structural and functional properties of the human liver in vivo. The microphysiological system consists of two compartments. The liver compartment consists of hepatocytes and hepatic stellate cells. The adjacent vascular compartment, which simulates blood flow, contains sinusoidal hepatic endothelial cells and macrophages, which serve as replacements for the Kupffer cells of the liver. The perfused platform can be operated with various cell sources and creates a stable physiological microenvironment for up to 14 days. The liver organ chip can be used in various studies. It is suitable for evaluating the effectiveness and toxicity of preclinical drug candidates, as well as for in-depth research into various infectious and inflammatory diseases of the liver. The method can thereby help to accelerate drug development, optimize existing therapeutic approaches, and generate new insights into pathological mechanisms at the cellular level.
Liver-on-chip
info@dynamic42.com
Added on: 04-05-2024
[1] https://dynamic42.com/liver-on-chip/
