Association between Helicobacter pylori and Alzheimer's disease
December 2023
McGill University, Montreal, Canada
This population-based study assessed whether clinically apparent Helicobacter pylori infection is associated with the risk of Alzheimer's disease (AD).
Therefore, a population-based cohort of all dementia-free subjects in the United Kingdom’s Clinical Practice Research Datalink, which contains anonymized medical records from general practitioners including medical diagnoses and procedures, was used. Within the study cohort, all cases with a first-time diagnosis of AD were identified. Each AD case was matched to up to 40 AD-free controls. All cases and controls were screened for clinically apparent Helicobacter pylori infection and salmonellosis as a negative control.
Among 4,262,092 dementia-free subjects, 40,455 developed AD within 11 years. Clinically apparent Helicobacter pylori infection increased the risk to develop Alzheimer's disease by 11 % in individuals aged ≥50 years.
Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer’s disease: A population-based nested case-control study
Paul Brassard
Added on: 01-13-2024
[1] https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13561[2] https://www.bionity.com/en/news/1182289/infection-with-stomach-bacteria-may-increase-risk-of-alzheimer-s-disease.html?utm_source=newsletter&utm_medium=email&utm_campaign=bionityde&WT.mc_id=ca0264
