Developmental toxicity assay for the specific detection of teratogenic drug compounds
CompanyToxys Europe, Oegstgeest, Netherlands
The ReproTracker from Toxys is a specially developed computer-based high-throughput screening assay for the identification of active ingredients and other bioactive substances that can lead to disorders of stem cell differentiation and malformations in early embryonic development. The method is based on the controlled cultivation and differentiation of human induced pluripotent stem cells into specific tissue types, which allows relevant steps in cellular embryogenesis to be observed and investigated. Using high-resolution imaging screening methods, functional and morphological expression patterns of relevant biomarkers are analysed to evaluate the toxic properties. ReproTracker shows high sensitivity and reliably detects specific teratogenic drug compounds and enables prediction of possible drug-induced pathological consequences for the growing embryo. In summary, the assay platform could help accelerate the safety testing of new active ingredients and improve drug treatment options for pregnant women.
ReproTracker
info@toxys.com
Added on: 11-08-2023
[1] https://toxys.com/reprotracker/
