Assay-based screening platforms for identifying DNA-damaging agents and researching potential antagonists
CompanyPrediTox, Toulouse, France
To identify and evaluate exogenous and endogenous DNA-damaging agents that can, among other things, promote the development of cancer, the company PrediTox has developed the test procedures PrediProtect and PrediRepair. The screening platforms are based on an examination of the phosphorylation of the biomarker H2AX (γH2AX), through which different types of genotoxic compounds can be detected. The PrediProtect assay is specifically designed for the detection of reactive oxygen species (ROS). The test enables the determination of compounds that induce oxidative stress, as well as an evaluation of possible antioxidant counterparts that serve to defend against ROS and counteract the cell ageing process. The PrediRepair assay was developed to detect compounds that can help repair genetic damage that has already occurred. The Predi-assays from PrediTox enable a predictive safety assessment of active ingredients to be tested and can help to reduce drug-induced damage and improve the development of relevant (cancer) therapeutics.
Antioxidant effect and DNA repair
contact@preditox.fr
Added on: 10-19-2023
[1] http://preditox.fr/en/service/antioxidant-effect/[2] http://preditox.fr/en/service/dna-repair/
