Human genetic data and in-silico-approaches reveal new cancer mechanisms
2020
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
Using highly sensitive analytical methods (whole-genome sequencing, whole-exome sequencing, RNAseq) and in silico methods, human-relevant, clinically highly relevant data were obtained, showing a much higher incidence of chromothripsis than previously assumed. In addition, it has been shown that these genetic events do not only occur at an early stage but also in late stages or in relapses. The prevalence of genomic instability was previously estimated at a few per cent, but in fact, it occurs in half of the tumour samples investigated. Chromosomes break and the parts are either lost or incorrectly reassembled. These events play an important role in the development of cancer.
The landscape of chromothripsis across adult cancer types
Aurélie Ernst
Added on: 06-25-2020
[1] https://www.nature.com/articles/s41467-020-16134-7[2] https://www.bionity.com/en/news/1166584/explosion-in-cancer-genome-much-more-common-than-expected.html
