Proteomic analysis identifies mechanisms related to chemoradiation resistance
December 2018
Institute of Molecular Medicine and Cell Research, Freiburg, Germany
Tha authors analyzed the tumor proteomes of primary pancreatic ductal adenocarcinoma (PDAC) patients subjected to additive chemoradiation after surgical resection. Results from patients achieving short versus prolonged progression-free survival are compared. The study investigates the responsiveness of PDAC patients to chemoradiation and provides further evidence for a role of Aldehyde Dehydrogenase 1 Family Member A1 (ALDH1A1) in therapy resistance.
Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance
Oliver Schilling
Added on: 04-21-2020
[1] https://www.sciencedirect.com/science/article/pii/S193652331830175X?via%3Dihub
