Human neuronal cell culture for pesticide screening
2020
Universidad Complutense de Madrid, Madrid, Spain
The indiscriminate application of Glyphosate may be a concern regarding the possible health and environmental hazards. To investigate the toxic effects of glyphosate and its metabolite AMPA, the human neuroblastoma SH-SY5Y cell line was used. This is an in vitro model to study effects related to neurotoxicity, oxidative stress and neurodegenerative diseases. This study demonstrates that glyphosate and AMPA can induce cell death promoting the involvement of oxidative stress, apoptosis, autophagy and necrosis mechanisms by alteration and /or upregulation of respective genes. The cell culture can serve as a useful model for pesticide screening.
Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways
Marta Martínez, Arturo Anadón
Added on: 08-16-2023
[1] www.sciencedirect.com/science/article/pii/S0160412019332507?via%3Dihub
