Glyphosate exposure and urinary oxidative stress biomarkers
2023
National Cancer Institute, Bethesda, USA
As there is limited epidemiologic data on one of the most used pesticides worldwide, Glyphosate, and controversial interpreted data in general, this study aims to shed light on the carcinogenic potential. Glyphosate may induce oxidative stress, which is a key characteristic of carcinogens. By analysing certain biomarkers in human urine from farmers who are and were exposed to Glyphosate and Glyphosate-based Herbicides (GBH), oxidative stress can be determined. Urinary glyphosate concentrations were quantified using ion chromatography isotope-dilution tandem mass spectrometry. Biomarkers were quantified using enzyme-linked immunosorbent assays with thiobarbituric acid reactive substances. Those were elevated, supporting the association of exposure to Glyphosate and urinary biomarkers of oxidative stress, which may contribute to development of certain cancers.
Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study
Vicky C. Chang
Added on: 08-16-2023
[1] www.academic.oup.com/jnci/article/115/4/394/6984725
