Combined laser and software technology to study functional and structural cardiotoxicity
CompanyForesee Biosystems, Genova, Italy
Foresee Biosystems has developed the so-called IntraCell platform to research short-term (functional) and long-term (structural) damage to heart muscle cells. The platform combines laser-based technologies with Microelectrode Array (MEA) technology, enabling the monitoring of the electrophysiological activity of cultured myocardial cells and simultaneous optical microscopic assessment of the cell morphology. The cells are automatically examined using control software that documents the experiments in real time (photos, videos). At the beginning of the experiment, the user can use the software to specify individually desired research parameters (electrode selection, laser scan parameters, examination period, MEA layout). With IntraCell, the action potentials of a single cell can be monitored over a period of a few hours to several weeks. This enables the identification of acute as well as chronic cardiotoxic agents. Several heart-damaging substances from the CiPA list have already been validated using the method in various test series. The computer-aided combination of electrophysiological and microscopic technologies enables non-invasive research into functional and, for the first time, chronic cardiotoxicities in vitro and can help to improve drug development.
IntraCell
info@foreseebiosystems.com
Added on: 07-25-2023
[1] https://foreseebiosystems.com/products/intracell/
