Mechanism of chemotherapeutic drug resistance under cellular stress
2020
Leibniz-Institut für Analytische Wissenschaften ISAS e.V., Dortmund, Germany(1)
Universität Regensburg, Regensburg, Germany(2)
University of Vienna, Vienna, Austria(3)
Universität Regensburg, Regensburg, Germany(2)
University of Vienna, Vienna, Austria(3)
A multi-omics approach was used to observe changes in gene expression after the induction of an unfolded protein response (UPR) pathway, with parallel study of the transcriptome, proteome and translation changes. By filtering, the induction of 267 genes, many of which were previously not involved in stress response pathways, could be identified. These pathways play a key role in numerous diseases and are involved in cancer growth and chemoresistance.
A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
Robert Ahrends(1, 3), Jan Medenbach(2)
Added on: 06-23-2020
[1] https://www.nature.com/articles/s41467-020-16747-y[2] https://www.bionity.com/en/news/1166683/cellular-stress-causes-cancer-cell-chemoresistance.html
