iPSC-derived neurons from PTSD patients
October 2022
Icahn School of Medicine at Mount Sinai, New York, USA(1)
The New York Stem Cell Foundation Research Institute, New York, USA(2)
The New York Stem Cell Foundation Research Institute, New York, USA(2)
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute to individual clinical outcomes is unknown. Here, the researchers compared transcriptional responses to hydrocortisone exposure in human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons and peripheral blood mononuclear cells (PBMCs) from combat veterans with PTSD and controls. In neurons only, the authors observed diagnosis-specific glucocorticoid-induced changes in gene expression corresponding with PTSD-specific transcriptomic patterns found in human postmortem brains. These findings suggest that induced neurons represent a platform for examining the molecular mechanisms underlying PTSD, identifying biomarkers of stress response, and conducting drug screening to identify new therapeutics.
Modeling gene x environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Rachel Yehuda(1), Kristen J. Brennand(1), Daniel Paull(2)
Added on: 04-25-2023
[1] https://www.nature.com/articles/s41593-022-01161-y[2] https://www.drugtargetreview.com/news/105917/stem-cell-study-reveals-how-neurons-from-ptsd-patients-react-to-stress/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Techne+-+Stem+Cells+-+14.04.2023&utm_term=Researchers+have+sculpted+the+human+body+plan+in+a+dish&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=U%2bnuX5GPJDY2jIV3GvDfT6iAI68vYD3G%2bgyu9QoRLxIvOEZ97RXsOZTww3cIfk3YfbioIUlodjkAhrAMB8ejiDfn%2f5HevPgdsXxAucltqHf1899tu22%2bEqAmDdvDe88I32aDlqOZK9CQ0wQqtqLyjVP162oysdiLXFcpifKj33Of2XSsrcG0hh3XvNMs4gs%2beZdusSpxOILpYlgUbD6xyxgjTrbKpijVejkG9e%2foST%2fFU85yDIkVSsasMF9RiUI1
