Blood–brain barrier (BBB)-on-a-chip for Alzheimer’s disease
2023
Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain
Here, the researchers developed a blood–brain barrier (BBB)-on-a-chip (BBB-oC) platform with a trans-endothelial electrical resistance (TEER) measurement system at a close distance to the barrier. The system characterization displayed a neurovascular network and the expression of tight junctions in the endothelium. It was used for the first time to evaluate the permeability performance of targeted gold nanorods for theranostics of Alzheimer’s disease. The BBB-oC with a novel TEER integrated setup was proven as a functional and throughput platform to evaluate the brain permeability performance of nanotherapeutics in a physiological environment with human cells.
BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer’s disease
Anna Lagunas, Mònica Mir
Added on: 04-24-2023
[1] https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-01798-2
