Cerebral organoids for multiple sclerosis variants research
2023
Tisch Multiple Sclerosis Research Center of New York, New York, USA
Multiple sclerosis is an inflammatory autoimmune disease in which the protective myelin layer of nerve cells is attacked and destroyed. Using patient-specific organoids (plus control organoids from healthy donors), all 3 main forms of MS (relapsing-remitting MS = RRMS, secondary progressive MS = SPMS, and primary progressive MS = PPMS) could be recapitulated. By this, the (possible) differences between the various forms of progression could also be investigated. These organoids revealed that in the MS forms, but especially in PPMS, the differentiation of oligodendrocytes is decreased compared to the healthy organoids, i.e. the cells responsible for building up myelin. Moreover, a lower expression of the cell cycle inhibitor p21 was found, which could be a possible therapeutic approach.
Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect
Saud A. Sadiq
Added on: 04-12-2023
[1] https://journals.biologists.com/bio/article/12/3/bio059845/294618/Cerebral-organoids-in-primary-progressive-multiple
