Bioprinted glioblastoma-on-a-chip
2019
Pohang University of Science and Technology, Pohang, South Korea(1)
Seoul National University College of Medicine, Seoul, South Korea(2)
Seoul National University College of Medicine, Seoul, South Korea(2)
Within this study, a bioprinted glioblastoma tumor model consisting of patient-derived tumor cells, vascular endothelial cells and decellularized extracellular matrix is demonstrated. The model is integrated into a concentric-ring structure that sustains a radial oxygen gradient, and recapitulates the structural, biochemical and biophysical properties of the native tumors. It was shown that the glioblastoma-on-a-chip reproduces clinically observed patient-specific resistances to treatment with concurrent chemoradiation and chemotherapy, and that the model can be used to identify drug combinations associated with superior tumor killing.
The patient-specific tumor-on-a-chip model might be useful for the identification of effective treatments for glioblastoma patients resistant to the standard treatment.
A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy
Dong-Woo Cho(1), Sun Ha Paek(2)
Added on: 04-04-2023
[1] https://www.nature.com/articles/s41551-019-0363-x
