Tissue-based map of the human proteome
2015
KTH—Royal Institute of Technology, Stockholm, Sweden
Here, the researchers present a freely available interactive resource as part of the Human Protein Atlas portal (www.proteinatlas.org), offering the possibility to explore the tissue-elevated proteomes in tissues and organs and to analyse tissue profiles for specific protein classes. Samples representing all major tissues and organs (n = 44) in the human body have been analysed to generate a map of the human tissue proteome. This was achieved using quantitative transcriptomics on a tissue and organ level, combined with the profiling of the spatial localization of proteins down to the single-cell level. The study provides a global analysis of the secreted and membrane proteins and an analysis of the expression profiles for all proteins targeted by pharmaceutical drugs and proteins implicated in cancer.
Tissue-based map of the human proteome
Mathias Uhlén
Added on: 03-15-2023
[1] https://www.science.org/doi/10.1126/science.1260419?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed[2] https://www.proteinatlas.org/
