Multielectrode arrays to study human motor neurons in vivo
November 2022
Chalmers University of Technology, Gothenburg, Sweden(1)
Imperial College London, London, United Kingdom(2)
Imperial College London, London, United Kingdom(2)
Within this study, a high-density intramuscular electrode for in vivo human recordings was developed along with a fully automatic methodology for the detection of the discharges of action potentials of up to 67 concurrently active motoneurons.
The thin-film electrode array contained 40 electrodes and the flexibility of the array allowed its insertion into the hole of a needle. Thus the intramuscular implantation of the electrodes could be performed with needles. Four intramuscular electrode arrays were tested in three healthy subjects. The volunteers were asked to contract the muscles with different intensities and signals of motor neurons were recorded and analyzed.
The system was shown to be able to analyze the human motor system in vivo.
Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles
Silvia Muceli(1), Dario Farina(2)
Added on: 03-13-2023
[1] https://www.science.org/doi/10.1126/sciadv.abo5040
