Basal ganglia organoids to study Tourette Syndrome
November 2022
Yale University, New Haven, USA
Tourette Syndrome (TS) is a neuropsychiatric disorder thought to involve a reduction of basal ganglia (BG) interneurons and malfunctioning of the BG circuitry. However, whether interneurons fail to develop or are lost postnatally remains unknown. To investigate the pathophysiology of early development in TS, induced pluripotent stem cell (iPSC)-derived BG organoids from TS patients and healthy controls were compared on multiple levels of measurement and analysis. BG organoids from TS individuals manifested differentiation and transcriptomic differences, revealing organoid mispatterning in TS. This study uncovers early neurodevelopmental underpinnings of TS neuropathological deficits using organoids as a model system.
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Flora M. Vaccarino
Added on: 01-19-2023
[1] https://www.nature.com/articles/s41380-022-01880-5[2] https://neurosciencenews.com/tourette-brain-organoid-22281/
