T cell responses predict progression of amyotrophic lateral sclerosis
November 2022
Karolinska Institutet, Stockholm, Sweden
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T-cell infiltration in the central nervous system. However, the contribution of T-cell responses to the pathology of the disease is not fully understood. Here the researchers show, by analysing blood and cerebrospinal fluid (CSF) samples of 89 newly diagnosed ALS patients, that T-cell phenotypes at the time of diagnosis are good predictors of disease outcome. Certain types of T-cells in blood and CSF are associated with poor survival, whereas other types of T-cells in the blood are associated with better survival. Besides survival, phenotypic profiling of T-cells could also predict disease progression rate. In summary, T-cell responses are associated with and likely contribute to disease progression in ALS, supporting the modulation of adaptive immunity as a viable therapeutic option.
T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
Fang Fang, John Andersson
Added on: 01-05-2023
[1] https://www.nature.com/articles/s41467-022-34526-9
