Organ-on-a-chip platforms for analysis of metastasis
2021
Izmir Institute of Technology, Izmir, Turkey
As metastasis is a major obstacle for breast cancer patients, model systems are needed to predict the metastatic potential of cancer cells. Two organ-on-chip platforms were developed for the quantitative assessment of invasion and extravasation towards specific tissues. Lung, liver and breast microenvironments were simulated in the chips using tissue-specific cells embedded in a gel matrix. Different breast cancer cell lines were tested using these two platforms. Both invasion/chemotaxis and extravasation results were in agreement with published clinical data.
On-chip determination of tissue-specific metastatic potential of breast cancer cells
Devrim Pesen-Okvur, Ozden Yalcin-Ozuysal
Added on: 12-06-2022
[1] https://onlinelibrary.wiley.com/doi/10.1002/bit.27855
