Testing of anti-cancer drugs using a Lab-on-a-chip platform
2020
Izmir Institute of Technology, Izmir, Turkey
Organ-on-a-chip or Lab-on-a-chip devices combined with human 3D cell models are promising tools for human-relevant drug screening. Three different cell models (breast cancer cells, normal mammary epithelial cells and macrophages) were grown on a Lab-on-a-chip platform emulating the cancer microenvironment. The established anti-cancer drug DOX and the new drug candidate KLA were tested using this system. Both drugs were effective on breast cancer cells, while DOX showed higher cytotoxicity and was not selective between breast cancer cells and normal mammary epithelial cells. This platform is a promising tool for the assessment of drug toxicity at the preclinical stage.
A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices
Devrim Pesen-Okvur
Added on: 12-06-2022
[1] https://www.sciencedirect.com/science/article/abs/pii/S0928098720303304?via%3Dihub
