Retinal cell map for retinal diseases therapies
2022
National Eye Institute, Bethesda, USA
Retinal degenerative diseases affect specific regions of the retinal pigment epithelium (RPE), suggesting the presence of functionally different RPE subpopulations. To identify these subpopulations in human eyes, the researchers generated the first complete morphometric map of the RPE at single-cell resolution using artificial intelligence-based software. They identified five concentric RPE subpopulations, including a ring of RPE cells with a cell area similar to the macula in the periphery of the eye. Moreover, they found that specific RPE subpopulations are differentially susceptible to monogenic and polygenic retinal diseases. The results obtained here will allow the study of molecular and functional RPE differences responsible for regional retinal diseases and will help develop precise cell and gene therapies for specific degenerative eye diseases.
Single-cell-resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity
Kapil Bharti
Added on: 11-25-2022
[1] https://www.pnas.org/doi/full/10.1073/pnas.2117553119[2] https://www.drugtargetreview.com/news/103076/retinal-cell-map-could-advance-precise-cell-and-gene-therapies-for-retinal-diseases/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Ncardia+-+Cell+and+Gene+Therapy+-+20.05.22&utm_term=A+new+target+for+CAR+T+cells+in+solid+tumours&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=ou3ohopfQ2ABP6%2byAqZNZmAdGXvjGfdCkRu3%2fLvNcJ0lCnw3Y1%2bbn5qF3mVOBCRn6%2fRrgiFReaKTiROJVJlWbYEKYoOaQ%2b1yTcTT3dsw8FNt0LVUnPc60PQJhWg3zduKRkU4cg9ftY6FZ9BlBFH2iFg5sV%2bK7N6iMooFddL4XH20T3DL4hOAEKs4yeSO4%2f%2fEbYvBTSt0EzSQOr27L694p6GeH3rJ3BIgIspIlxUQhfpnsHP83VYPESGdbQq2UMHSEimrx0r8wP9gZil3QLvCVA%3d%3d
