Genetic study identifies therapeutic targets for migraines
2022
Queensland University of Technology (QUT), Brisbane, Australia
Migraine is a common complex disorder with a significant polygenic single-nucleotide polymorphism (SNP) heritability. Here, the researchers utilise genome-wide association study (GWAS) summary statistics to study pleiotropy between blood proteins and migraine under the polygenic model. They collected 4625 publicly available GWAS summary statistics for blood proteins and explored the extent of pleiotropy between migraine and the 325 blood proteins. Pleiotropy analyses link 58 blood proteins to migraine risk at genome-wide, gene and/or single-nucleotide polymorphism levels—suggesting shared genetic influences or causal relationships. The study suggests that Wnt activators that restore Wnt/β-catenin signalling in the brain could represent therapeutic tools against migraine.
Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine
Hamzeh M. Tanha, Dale R. Nyholt
Added on: 11-25-2022
[1] https://www.nature.com/articles/s41467-022-30184-z[2] https://www.drugtargetreview.com/news/103122/genetic-study-identifies-promising-therapeutic-targets-for-migraines/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Newsletter+21+-+Fluidigm+-+26.05.2022&utm_term=Preclinical+study+highlights+an+effective+combination+immunotherapy+for+liver+cancer&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=4qit8JELXMNLYYd5ReuNgqUkhfuL9o6DxQzoc6MdzF2ZF4ofHGHA5KdwbB%2b11u%2fZS8I9uOA9yu%2bBXMWx5iMVaNDvDEmZGmeNgNrF%2f0AeRPFxs8EUqkTbtCHypNfC%2f2BoVmSfdKLKhtGtLOCO%2fV9tjwKQuAlB0NrhpD2%2fEnrMmQDmMNFZg50VhVAPf1%2fruAgVY0nF%2bMQBJepK%2fCqthQYQueQ%2f7PhOAvdBslZOjCIzozA%3d
