Alzheimer's Disease model with de novo TAUopathies
CompanyNeuron-D GmbH, Dresden, Germany
To simulate the endogenous development of human neurons and mimic neurodegeneration processes, the company Neuron D has established novel 3D hydrogel cell cultures based on human neural stem cells.
The modular hydrogel system allows independent control of physical (stiffness, swelling) and biochemical properties (presentation of adhesion ligands and glycosaminoglycan-binding signalling molecules) as well as localized cell-regulated transformation via enzymatically cleavable peptide units.
Neural networks can be generated by incorporating human neural stem cells into the matrix. The function and morphology of the neurons correspond to human cortical neurons, as evidenced by matching molecular markers and electrophysiological functions.
In the 3D Alzheimer's model, the neural networks are used to simulate pathological changes, such as the amyloid toxicity known to occur in Alzheimer's disease. Consistent with clinical symptoms, the model results in neuronal cell death, loss of active synaptic connections and neuronal connectivity, decreased neural stem cell proliferation and neurogenesis, loss of neuronal marker expression in the cortices, and formation of TAU pathology.
3D-AD
info@neurond.de
Added on: 11-21-2022
[1] https://neurond.de/3d-alzheimers-%26-taupathy
