Photo-thermal therapy (PTT) is a minimally invasive cancer treatment that relies on the capability of photosensitizing agents to generate highly localized thermal heating for the selective thermal ablation of tumors. This study reports on a powerful combination of 3D bioprinting (3DB) and PTT applications. To this end, the researchers realize a 3DB construct consisting of glioblastoma U87-MG cells in a 3D geometry, incorporating biomimetic keratin-coated gold nanoparticles (Ker-AuNPs) as a photo-thermal agent. The resulting plasmonic 3DB structures exhibit a homogeneous cell distribution throughout the entire volume while promoting the localization of Ker-AuNPs within the cells. Laser-assisted PTT experiments demonstrate the extraordinary ability of Ker-AuNPs to generate heating, producing the highest temperature rise of about 16 °C in less than 2 min.
Biomimetic keratin-coated gold nanoparticles for photo-thermal therapy in a 3D bioprinted glioblastoma tumor model
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