Novel synthetic clot analogs for in vitro stroke modelling
2022
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
The increased demand for the training of mechanical thrombectomy in ischemic stroke and the development of new recanalization devices urges the creation of new simulation models both for training and device assessment. Clots properties have been shown to play a role in procedural planning and thrombectomy device effectiveness. In this study, the researchers analysed the characteristics and applicability of completely synthetic, animal-free clots in the setting of an in vitro model of mechanical thrombectomy for training and device assessment. Synthetic clots based on agarose and silicone were evaluated in an in-vitro neurointervention simulation of mechanical thrombectomy with clot extraction devices. Calcified clots of mixed nature were simulated with the addition of 3D-printed structures. Both agarose-based and silicone-based clots demonstrated relevant flow arrest and good integration with the clot extraction device. Silicone-based clots scored higher on adherence to the vessel wall and elasticity. Selected synthetic clots can successfully be implemented in an in-vitro training environment of mechanical thrombectomy. The clots' different properties might serve to mimic fibrin-rich and red blood cell-rich human thrombi.
Novel synthetic clot analogs for in-vitro stroke modelling
Helena Guerreiro
Added on: 10-25-2022
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0274211
