Single-cell mapping identifies cell type–specific genetic control of autoimmune disease
2022
Garvan Institute of Medical Research, Sydney, Australia(1)
University of Tasmania, Hobart, Australia(2)
University of Tasmania, Hobart, Australia(2)
The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune disease. This work brings together population genetics and single-cell RNA (scRNA)-seq data to uncover drivers of interindividual variation in the immune system. Single-cell RNA sequencing data (scRNA-seq) of peripheral blood mononuclear cells from 982 healthy human volunteers are used for this purpose. The study's results demonstrate how segregating genetic variation influences the expression of genes that encode proteins involved in critical immune regulatory and signalling pathways in a cell type-specific manner. Understanding the genetic underpinnings of immune system regulation will have broad implications in the treatment of autoimmune diseases and infections, transplantation, and cancers.
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease
Joseph E. Powell(1), Alex W. Hewitt(2)
Added on: 09-13-2022
[1] https://www.science.org/doi/10.1126/science.abf3041[2] https://www.technologynetworks.com/immunology/news/immune-fingerprint-could-improve-success-of-autoimmune-disease-treatments-360461
