Machine-assisted discovery toward sustained neural regeneration
2022
Princeton University, Princeton, USA(1)
The State University of New Jersey, Piscataway, USA(2)
The State University of New Jersey, Piscataway, USA(2)
Shortly after spinal cord injury, a secondary inflammatory cascade creates dense scar tissue that can inhibit or prevent nerve tissue regeneration. The enzyme ChABC degrades scar tissue after spinal cord injury and promotes tissue regeneration. However, it is highly unstable at human body temperature and loses all activity within a few hours. In this study, ChABC was stabilized by formulation through the use of artificial intelligence (AI) and robotics such that its activity was prolonged by a large amount.
Synthetic copolymers are able to wrap around enzymes such as ChABC and stabilize them in hostile microenvironments. To stabilize the enzyme, researchers used an AI-driven approach with liquid robots to synthesize numerous copolymers and test their ability to stabilize ChABC and maintain its activity at human body temperature for up to a week.
Machine-assisted discovery of chondroitinase ABC complexes toward sustained neural regeneration
Michael A. Webb(1), Adam J. Gormley(2)
Added on: 09-12-2022
[1] https://onlinelibrary.wiley.com/doi/10.1002/adhm.202102101[2] https://www.technologynetworks.com/neuroscience/news/ai-designs-enzyme-to-accelerate-recovery-from-spinal-cord-injury-359352
