Novel in silico tool for studying autoimmune diseases related to COVID-19
2022
Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea
The development of autoimmune diseases following SARS-CoV-2 infection, including multisystem inflammatory syndrome, has been reported, and several mechanisms have been suggested, including molecular mimicry. The researchers developed a scalable, comparative immunoinformatics pipeline called cross-reactive-epitope-search-using-structural-properties-of-proteins (CRESSP) to identify cross-reactive epitopes between a collection of SARS-CoV-2 proteomes and the human proteome using the structural properties of the proteins. They identified 133 and 648 human proteins harbouring potential cross-reactive B-cell and CD8+ T-cell epitopes, respectively. To demonstrate the robustness of the pipeline, the authors predicted the cross-reactive epitopes of coronavirus spike proteins, which were recognized by known cross-neutralizing antibodies. Finally, they developed a web application (https://ahs2202.github.io/3M/) to interactively visualize these results and made the pipeline available as an open-source CRESSP package (https://pypi.org/project/cressp/), which can analyse any two proteomes of interest to identify potentially cross-reactive epitopes between the proteomes. Overall, these immunoinformatic resources provide a foundation for the investigation of molecular mimicry in the pathogenesis of autoimmune and chronic inflammatory diseases following COVID-19.
CRESSP: a comprehensive pipeline for prediction of immunopathogenic SARS-CoV-2 epitopes using structural properties of proteins
Jihwan Park
Added on: 09-08-2022
[1] https://academic.oup.com/bib/article-abstract/23/2/bbac056/6539139?redirectedFrom=fulltext&login=false[2] https://www.drugtargetreview.com/news/103193/a-novel-tool-for-studying-autoimmune-diseases-related-to-covid-19/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Thermo+Fisher+-+Lab+Automation+-+03.06.22&utm_term=New+machine+learning+technique+to+develop+new+drugs&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=7fjQZ2dXMWRo0TTxTaLpc66pHkJKGkKovqljZfpFAQtYmgCox7oSCPkwyS0dW%2fn%2fKqMgmIelmMI9oCi6z2C2BO9eSFqg0i8omoxtQQX%2bwNDC4uIwGaBMLvT9CYYIm1MRfEm2ten9tDa%2fU6sq9joEKKOZdVqewEGCiAbt%2fxUmmqoEndZXCK7lY7bS%2f6qzaJUeAwV2LyXy3%2fJOIiojxP%2bRFiK%2f0wRrZIkFysWMnBBriDik%2f7e2HZjFioejerenphzs0WlymulB0FHkBXBOFRlPKQ%3d%3d
