Organoid cultures suitable for long-term breast cancer studies
2020
Harvard Medical School, Boston, USA
The authors present an extensive evaluation of the ability of organoid culture technology to preserve complex stem/progenitor and differentiated cell types via long-term propagation of mammary tissues from healthy people and cancer patients. Single-cell analyses demonstrate that protein expression patterns of the tissue of origin can be preserved in organoid culture. This indicates that organoid cultures provide a valuable platform for studies of mammary differentiation, transformation, and breast cancer risk.
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
Joan S. Brugge
Added on: 05-26-2020
[1] https://www.nature.com/articles/s41467-020-15548-7
